CHMP2B polyclonal, anti-human, mouse, rat

Background:
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Synonyms: ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B

Cellular Location: Cytoplasm Late endosome membrane Peripheral membrane protein cytosol

Immunogen:
Recombinant protein of human CHMP2B

Gene Symbol: CHMP2B

Gene ID: 25978

Swiss prot: Q9UQN3

Calculated MW: 24kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.