CHRNA10 Polyclonal Antibody

Background:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Research Area: Neuroscience, Signal Transduction

Synonyms:
Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit, ACH10, Alpha 10 nAChR, Cholinergic receptor nicotinic alpha 10, Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10, Cholinergic receptor, nicotinic, alpha polypeptide 10, CHRNA 10, CHRNA10, NACHR alpha 10, NACHR alpha-10, NACHRA10, Neuronal acetylcholine receptor protein subunit alpha 10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha 10, Nicotinic acetylcholine receptor subunit alpha-10, OTTHUMP00000013620

Immunogen: Synthetic peptide of human CHRNA10

Swissprot: Q9GZZ6
Gene Accession: NP_065135

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18277