CHRNA10 Polyclonal Antibody

Background:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Research Area: Neuroscience, Signal Transduction

Synonyms:
CHRNA10

Immunogen: Recombinant fusion protein of human CHRNA10 (NP_065135.2).

Swissprot: Q9GZZ6
Gene ID: 57053

Calculated MW: 49 kDa
Observed MW: 45 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:1000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.