CHRNA2 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP11942a
Background:
Nicotinic acetylcholine receptors (nAChRs) areligand-gated ion channels formed by a pentameric arrangement ofalpha and beta subunits to create distinct muscle and neuronalreceptors. Neuronal receptors are found throughout the peripheraland central nervous system where they are involved in fast synaptictransmission. This gene encodes an alpha subunit that is widelyexpressed in the brain. The proposed structure for nAChR subunitsis a conserved N-terminal extracellular domain followed by threeconserved transmembrane domains, a variable cytoplasmic loop, afourth conserved transmembrane domain, and a short C-terminalextracellular region. Mutations in this gene cause autosomaldominant nocturnal frontal lobe epilepsy type 4. Single nucleotidepolymorphisms (SNPs) in this gene have been associated withnicotine dependence.
Other Names:
Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
Gene Name: CHRNA2
Gene ID: 1135
Primary Accession: Q15822
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Nicotinic acetylcholine receptors (nAChRs) areligand-gated ion channels formed by a pentameric arrangement ofalpha and beta subunits to create distinct muscle and neuronalreceptors. Neuronal receptors are found throughout the peripheraland central nervous system where they are involved in fast synaptictransmission. This gene encodes an alpha subunit that is widelyexpressed in the brain. The proposed structure for nAChR subunitsis a conserved N-terminal extracellular domain followed by threeconserved transmembrane domains, a variable cytoplasmic loop, afourth conserved transmembrane domain, and a short C-terminalextracellular region. Mutations in this gene cause autosomaldominant nocturnal frontal lobe epilepsy type 4. Single nucleotidepolymorphisms (SNPs) in this gene have been associated withnicotine dependence.
Other Names:
Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
Gene Name: CHRNA2
Gene ID: 1135
Primary Accession: Q15822
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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