CHRNA4 (aa29-43) polyclonal, anti-human, rat

Background:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.

Other Names:
Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4

Antigen Types:
Synthetic Peptide

Gene Name:
CHRNA4
Gene ID:
1137
Primary Accession: P43681
Other Accession: NP_000735;1137;11438 (mouse); 25590 (rat);