CHRNA4 polyclonal, anti-mouse

Background:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.

Synonyms: BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4

Cellular Location: Cell junction Cell membrane Lipid-anchor Multi-pass membrane protein postsynaptic cell membrane synapse

Immunogen:
Recombinant protein of human CHRNA4

Gene Symbol: CHRNA4

Gene ID: 1137

Swiss prot: P43681

Calculated MW: 70kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.