CHRNA7 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13898a
Background:
The nicotinic acetylcholine receptors (nAChRs) are membersof a superfamily of ligand-gated ion channels that mediate fastsignal transmission at synapses. The nAChRs are thought to behetero-pentamers composed of homologous subunits. The proposedstructure for each subunit is a conserved N-terminal extracellulardomain followed by three conserved transmembrane domains, avariable cytoplasmic loop, a fourth conserved transmembrane domain,and a short C-terminal extracellular region. The protein encoded bythis gene forms a homo-oligomeric channel, displays markedpermeability to calcium ions and is a major component of brainnicotinic receptors that are blocked by, and highly sensitive to,alpha-bungarotoxin. Once this receptor binds acetylcholine, itundergoes an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel acrossthe plasma membrane. This gene is located in a region identified asa major susceptibility locus for juvenile myoclonic epilepsy and achromosomal location involved in the genetic transmission ofschizophrenia. An evolutionarily recent partial duplication eventin this region results in a hybrid containing sequence from thisgene and a novel FAM7A gene. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Other Names:
Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13898a was selected from the N-term region of CHRNA7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CHRNA7
Gene ID: 1139;89832
Primary Accession: P36544
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The nicotinic acetylcholine receptors (nAChRs) are membersof a superfamily of ligand-gated ion channels that mediate fastsignal transmission at synapses. The nAChRs are thought to behetero-pentamers composed of homologous subunits. The proposedstructure for each subunit is a conserved N-terminal extracellulardomain followed by three conserved transmembrane domains, avariable cytoplasmic loop, a fourth conserved transmembrane domain,and a short C-terminal extracellular region. The protein encoded bythis gene forms a homo-oligomeric channel, displays markedpermeability to calcium ions and is a major component of brainnicotinic receptors that are blocked by, and highly sensitive to,alpha-bungarotoxin. Once this receptor binds acetylcholine, itundergoes an extensive change in conformation that affects allsubunits and leads to opening of an ion-conducting channel acrossthe plasma membrane. This gene is located in a region identified asa major susceptibility locus for juvenile myoclonic epilepsy and achromosomal location involved in the genetic transmission ofschizophrenia. An evolutionarily recent partial duplication eventin this region results in a hybrid containing sequence from thisgene and a novel FAM7A gene. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Other Names:
Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13898a was selected from the N-term region of CHRNA7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CHRNA7
Gene ID: 1139;89832
Primary Accession: P36544
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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