CHRNA7 Polyclonal Antibody

Background:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Research Area: Cancer, Metabolism, Neuroscience

Synonyms:
7nAChR, a7 nicotinic acetylcholine receptor, acetylcholine receptor, neuronal nicotinic, alpha-7 subunit, ACHA7, AChR, Acra7, alpha 7 neuronal nicotinic acetylcholine receptor, alpha-7 nicotinic cholinergic receptor subunit, alpha7, cholinergic receptor, neuronal nicotinic, alpha polypeptide 7, cholinergic receptor, nicotinic, alpha 7 (neuronal), cholinergic receptor, nicotinic, alpha 7, cholinergic receptor, nicotinic, alpha polypeptide 7, CHRNA7, CHRNA7-2, NACHRA7, neuronal acetylcholine receptor protein, alpha-7 chain, Neuronal acetylcholine receptor subunit alpha-7

Immunogen: Synthetic peptide of human CHRFAM7A

Swissprot: P36544
Gene Accession: NP_683709

Calculated MW: 46 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31190140/