CHRNA9 N-terminal region polyclonal, anti-mouse, rabbit, horse, bovine, guinea pig, dog

Background:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Other Names:
Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9, CHRNA9, NACHRA9

Immunogen:
The immunogen for anti-CHRNA9 antibody: synthetic peptide directed towards the N terminal of human CHRNA9

Gene Name:
CHRNA9
Gene Name:
55584
NCBI Accession:
NP_060051
Primary Accession: Q9UGM1
Other Accession: NM_017581;NP_060051
Purification: Affinity Purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.