CHRNB2 middle region polyclonal, anti-human, mouse, rat, pig, dog, guinea pig, bovine

Background:
This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot and immunohistochemistry by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein.

Other Names:
Neuronal acetylcholine receptor subunit beta-2, CHRNB2

Target/Specificity:
Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.

Immunogen:
The immunogen for anti-CHRNB2 antibody: synthetic peptide directed towards the middle region of human CHRNB2

Gene Name:
CHRNB2
Gene Name:
1141
Swissprot ID: P17787
NCBI Accession:
NP_000739
Primary Accession: P17787
Other Accession: P17787;NP_000739;NM_000748
Purification: Protein A purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.