CHRNG polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP17105a
Catalog Number: AC-AP17105a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37063
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37063
Applications: WB
Datasheet
Request Information
Background:
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Other Names:
Acetylcholine receptor subunit gamma, CHRNG, ACHRG
Target/Specificity:
This CHRNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG.
Antigen Region:
22-50
Antigen Type: Synthetic Peptide
Gene Name: CHRNG (HGNC:1967)
Gene ID: 1146
Primary Accession: P07510
NCBI Accession: NP_005190.4
Other Accession: NP_005190.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Other Names:
Acetylcholine receptor subunit gamma, CHRNG, ACHRG
Target/Specificity:
This CHRNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG.
Antigen Region:
22-50
Antigen Type: Synthetic Peptide
Gene Name: CHRNG (HGNC:1967)
Gene ID: 1146
Primary Accession: P07510
NCBI Accession: NP_005190.4
Other Accession: NP_005190.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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