Chromogranin A Polyclonal Antibody

Background:
Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin,pancreastatin,catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). CgA is one of the most used tumor markers in NET's (neuroendocrine tumors) ,and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors.

Research Area: Cancer, Neuroscience, Signal Transduction, Tags and Cell Markers

Synonyms:
beta Granin, betagranin (N-terminal fragment of chromogranin A), catestatin, CgA, CHG A, Chga, chromofungin, Chromogranin A, Chromogranin A parathyroid secretory protein 1, Chromogranin A precursor, ChromograninA, CMGA, ER-37, Pancreastatin, Parastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Secretory protein I, SP I, SP-I, SP1, SPI, Vasostatin, Vasostatin I, Vasostatin II

Immunogen: Recombinant Mouse Chromogranin-A protein

Swissprot: P26339

Calculated MW: 51 kDa
Observed MW: 51 kDa

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:1000 IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.