cIAP-2/HIAP-1 polyclonal, anti-human, mouse, rat antibody

Background:
Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.

Other Names:
CIAP2 , cIAP2 , IAP1, AIP1, HIAP-1, HIAP1, API2, C-IAP2 , hiap-1, HAIP1, MIHC, MALT2, BIRC3

Primary Accession: Q13489

Gene Name: BIRC3

Gene ID: 330

Concentration (mg/ml): 0.2 mg/ml