CIITA Picoband polyclonal, anti-human, mouse, rat

Description: Rabbit IgG polyclonal antibody for MHC class II transactivator(CIITA) detection. Tested with WB, IHC-P in Human;Mouse;Rat.Protein Name: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). .

Protein Function:
|immunology|adaptive immunity|mhc|class ii|
epigenetics and nuclear signaling|transcription|other factors

Other Names: MHC class II transactivator, CIITA, 2.3.1.-, 2.7.11.1, CIITA, MHC2TA

Subcellular Localization: MHC class II transactivator;CIITA;2.3.1.-;2.7.11.1;CIITA;MHC2TA;

Tissue Specificity: MHC class II transactivator

Source: 123514 MW

Gene ID: 4261

Immunogen: E.coli-derived human CIITA recombinant protein (Position: E945-R1130). Human CIITA shares 84.4% amino acid (aa) sequence identity with mouse CIITA.

Calculated MW: 123514

Purification: Immunogen affinity purified.

Format: Lyophilized

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Concentration (mg/ml): Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.