CISH polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61295
Background:
Src homology (SH2) domains are noncatalytic sequences that are conserved among a number of cytoplasmic signaling proteins. These signaling proteins are directly regulated by receptor tyrosine kinases and control the activation of mitogenic signal transduction pathways by such receptors (1-3). For instance, ligand-induced activation of the EGF and PDGF receptors induces dimerization, triggers receptor autophosphorylation on tyrosine residues and results in the binding of a number of cytoplasmic SH2 domain proteins such as PLC-g1 (4,5), Ras GAP (6) and PI 3-kinase p85 (5) to the activated receptors (4,5). The Shc gene encodes proteins with a single SH2 domain but no identifiable catalytic domain. CIS, cytokine-inducible SH2-containing protein, is a 267 amino acid protein with a single 96 amino acid SH2 domain that associates the tyrosine-phosphorylated beta chain of the IL-3 receptor with the tyrosine-phosphorylated Epo receptor (7). CIS was initially described as an immediate early cytokine-responsive gene and appears to be a unique regulator of cytokine signaling (7).
Alternative Name:
Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS, CISH, G18
Application Dilution: WB: 1:500~1:1000
Specificity: CISH polyclonal antibody detects endogenous levels of CISH protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CISH.
MW: ~ 29 kDa
Swis Prot.: Q9NSE2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.5.
Storage:
Store at 4°C short term. Aliquot and store at -22°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Src homology (SH2) domains are noncatalytic sequences that are conserved among a number of cytoplasmic signaling proteins. These signaling proteins are directly regulated by receptor tyrosine kinases and control the activation of mitogenic signal transduction pathways by such receptors (1-3). For instance, ligand-induced activation of the EGF and PDGF receptors induces dimerization, triggers receptor autophosphorylation on tyrosine residues and results in the binding of a number of cytoplasmic SH2 domain proteins such as PLC-g1 (4,5), Ras GAP (6) and PI 3-kinase p85 (5) to the activated receptors (4,5). The Shc gene encodes proteins with a single SH2 domain but no identifiable catalytic domain. CIS, cytokine-inducible SH2-containing protein, is a 267 amino acid protein with a single 96 amino acid SH2 domain that associates the tyrosine-phosphorylated beta chain of the IL-3 receptor with the tyrosine-phosphorylated Epo receptor (7). CIS was initially described as an immediate early cytokine-responsive gene and appears to be a unique regulator of cytokine signaling (7).
Alternative Name:
Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS, CISH, G18
Application Dilution: WB: 1:500~1:1000
Specificity: CISH polyclonal antibody detects endogenous levels of CISH protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CISH.
MW: ~ 29 kDa
Swis Prot.: Q9NSE2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.5.
Storage:
Store at 4°C short term. Aliquot and store at -22°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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