CITED2(NT) polyclonal, anti-human, mouse antibody
€355.00
In stock
SKU
AC-ABV10889-100
Catalog Number: AC-ABV10889-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, E
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, E
Datasheet
Request Information
Background:
CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.
Other Names:
Cbp/p300-interacting transactivator 2, melanocyte-specific gene 1-related gene 1, MSG-related protein 1, MRG1, melanocyte specific gene 2, MSG2, ER154-like, ASD8, VSD2
Primary Accession: Q99967
Gene Name: CITED2
Gene ID: 10370
Concentration (mg/ml): 1 mg/ml
CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.
Other Names:
Cbp/p300-interacting transactivator 2, melanocyte-specific gene 1-related gene 1, MSG-related protein 1, MRG1, melanocyte specific gene 2, MSG2, ER154-like, ASD8, VSD2
Primary Accession: Q99967
Gene Name: CITED2
Gene ID: 10370
Concentration (mg/ml): 1 mg/ml
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