CITED4 Polyclonal Antibody

Background:
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
AU019445, AW742964, Cbp/p300 interacting transactivator 4, cbp/p300 interacting transactivator, with glu/asp rich carboxy terminal domain, 4, Cbp/p300-interacting transactivator 4, CITE4, Cited4, MRG 2, MRG-2, Mrg2, MSG1 related protein 2, MSG1-related protein 2, Transcriptional co-activator 4

Immunogen: Synthetic peptide of human CITED4

Swissprot: Q96RK1
Gene Accession: NP597724

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.