CK-17 Monoclonal Antibody

Background:
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Research Area: Cancer, Signal Transduction

Synonyms:
39.1, CK 17, CK-17, Cytokeratin-17, K17, K1C17, Keratin 17, keratin 17 epitope S1, keratin 17 epitope S2, keratin 17 epitope S4, Keratin 17, type I, Keratin, Keratin type I cytoskeletal 17, keratin, type i cytoskeletal 17 [version 1], Keratin-17, KRT17, PC, PC2, PCHC1, type I cytoskeletal 17

Immunogen: Synthetic Peptide

Swissprot: Q04695

Calculated MW: 48 kDa
Observed MW: 48 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.