CK-6A/B/C Monoclonal Antibody

Background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Research Area: Cancer, Signal Transduction, Tags and Cell Markers

Synonyms:
CK-6A, CK-6D, CK6A, CK6C, CK6D, Cytokeratin-6A, Cytokeratin-6D, K2C6A, K6A, K6C, K6D, keratin 6A, Keratin, Keratin, type II cytoskeletal 6A, Keratin-6A, Krt6a, KRT6C, KRT6D, type II cytoskeletal 6A, Type-II keratin Kb6

Immunogen: Synthetic Peptide

Swissprot: P02538,P04259,P48668

Calculated MW: 60 kDa
Observed MW: 56-60 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.