CK19 / CYFRA21-1 (Capture Ab) (clone D5), anti-human

Background:
-Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. KRT19 is also known as Cyfra 21-1. The usefulness of serum CYFRA 21-1 (cytokeratin-19 fragments) in monitoring the recurrence of breast cancer and in evaluating therapeutic effects. Serum CYFRA 21-1 may be a reliable marker of recurrence or therapeutic efficacy. The serum level of Cyfra21-1 was a useful biomarker for diagnosis of nonsmall cell lung cancer (NSCLC) as well. The serum cytokeratin 19 fragment 21.1 (CYFRA21-1) level was elevated in nasopharyngeal carcinoma (NPC) and can function as a biomarker for detection and monitoring of NPC. After analyzing NPC group and healthy control group, Song XM et al concluded that the serum CYFRA21-1 level could be a reliable and effective biomarker for the detection and monitoring of NPC tumor progression.-

Immunogen:
-40 KDa of Keratin 19 protein.-

Specificity:
-It specifically recognize the humanCK19 / CYFRA21-1, andmaycross react withCK20, CK8 & CK18.-

Matched antibody pair: -Capture Ab:CYFRA21-1 mAb (clone # D5), Detection Ab:CYFRA21-1 mAb (clone # C4)-

Recommended Application:
-Western Blot, WB; ELISA; Chemilumineseent immunoassay, CLIA;-

Product Form: -Liquid-

Purification & Buffer: -Protein A or G purified and supplied in 0.01 M PBS (pH7.4)& 0.15 M NaClwithout preservative.-

Purity: ->95% by HPLC & SDS-PAGE-

Storage Instruction:
-Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.