CKMT1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7071b
Background:
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
Other Names:
Creatine kinase U-type, mitochondrial, Acidic-type mitochondrial creatine kinase, Mia-CK, Ubiquitous mitochondrial creatine kinase, U-MtCK, CKMT1A, CKMT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7071b was selected from the C-term region of human CKMT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CKMT1A
Gene ID: 1159;548596
Primary Accession: P12532
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
Other Names:
Creatine kinase U-type, mitochondrial, Acidic-type mitochondrial creatine kinase, Mia-CK, Ubiquitous mitochondrial creatine kinase, U-MtCK, CKMT1A, CKMT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7071b was selected from the C-term region of human CKMT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CKMT1A
Gene ID: 1159;548596
Primary Accession: P12532
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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