ClassiX™ DNA/RNA

A single silica-bead chemistry for simultaneous DNA and RNA recovery, across a wide range of clinical sample types.

It's finally here. Developed from over 20 years of combined sample-preparation experience, ClassiX™ DNA/RNA delivers reproducible nucleic acid yields from 14 validated matrices and across bacterial, viral, fungal, and parasitic targets, including complex, inhibitor-rich matrices where recovery is hardest to achieve.

14 sample types on a single chemistry
Rather than a family of matrix- or pathogen-specific kits, ClassiX™ DNA/RNA covers 14 validated sample types and every major organism class with one chemistry and one protocol.
- Bacteria
- Viruses
- Fungi
- Parasites

GASTROINTESTINAL: Stool, Rectal swab
RESPIRATORY: nasopharyngeal swab*, Throat swab
BLOOD & SERUM: Whole blood, Serum
UROGENITAL: Urine, Vaginal swab, Semen
SWABS IN TRANSPORT MEDIAL: Swabs in UTM/VTM, Swabs in saline / PBS, Swabs in Amies medium, Swabs in eNAT
ENVIRONMENTAL: Wastewater

Validated target organism classes:
- Gram-negative bacteria: E. coli O157 · EPEC · EAEC · Shigella · Campylobacter · Aeromonas · N. gonorrhoeae
- Gram-positive bacteria: Staphylococcus aureus
- RNA & DNA viruses: SARS-CoV-2 · Dengue · TTV · human RNA targets
- Fungi: Candida albicans
- Parasites: Plasmodium falciparum
- Mollicutes / Atypicals: Mycoplasma genitalium · Ureaplasma urealyticum

DOWNSTREAM COMPATIBILITY
Clean eluates, ready for every detection platform
Guanidinium-salt wash and a detergent-free elution buffer produce eluates free of carry-over detergents and inhibitors. No additional cleanup, concentration, or nuclease treatment is required, the eluate can be used directly for your assay.
Elution volume is selectable from 50–200 µL to match downstream input requirements.

qPCR RT-qPCR: Validated across in-house and commercial assays on standard real-time platforms, for both DNA and RNA targets from the same eluate.
Multiplex PCR: Compatible with multi-target syndromic panels: evaluated with commercial STI, respiratory, and enteric panel assays.
dPCR, ddPCR: Clean, low-inhibitor eluates suit partition-based absolute quantification, where carry-over inhibitors are especially disruptive.
NGS library prep: Co-extracted DNA and RNA of suitable purity for sequencing workflows, including metagenomic and targeted panel library preparation.

AUTOMATION
Fully automatable on the SwiftXtractor™ SL & more:
The complete ClassiX™ DNA/RNA workflow runs end-to-end on the SwiftXtractor™ SL platform with the 15 mL/1.5 mL tube adapter. Load samples, press start, walk away: same chemistry, same protocol, automated.

AUTOMATION
Automated performance matches manual: In head-to-head testing, the automated protocol on SwiftXtractor™ SL matched or even improved manual extraction across matrices and yielded earlier Cq values on several urine targets (up to 3.3 Cq), automation without a performance trade-off.
Walk-away: Load samples, select the protocol, walk away; minimal operator variability.
Compact and Field-Deployable: SwiftXtractor™ SL weighs ~15 kg and runs on AC or DC power. Deploy at treatment plants, mobile labs, or field stations.
One vendor: Single support contract and validation pathway, simpler procurement.

Clinical Evaluation
Evaluated on authentic clinical specimensBeyond spiked and contrived samples, ClassiX™ DNA/RNA has been evaluated on clinically sourced urine and urogenital specimens processed on the SwiftXtractor™ platform from a 200 µL input, with a 100 µL elution.