Claudin 1 (CLDN1) Antibody (Loop2) Blocking peptide
€363.00
In stock
SKU
AC-BP6308b
Background:
CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Other Names:
Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6308b was selected from the Loop2 region of human CLDN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CLDN1
Gene ID: 9076
Primary Accession: O95832
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Other Names:
Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6308b was selected from the Loop2 region of human CLDN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CLDN1
Gene ID: 9076
Primary Accession: O95832
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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