Claudin 1 CLDN1 monoclonal, anti-human, mouse, rat

Description: Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391)..

Other Names: Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1

Clone Name(s):
Clone: ABEH-3

Subcellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Tissue Specificity: Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis..

Gene ID: 9076

Immunogen: A synthesized peptide derived from human Claudin 1

Calculated MW: 22744

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.