Claudin 1 Polyclonal Antibody

Background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Research Area: Cancer, Signal Transduction

Synonyms:
Claudin-1, Claudin1, CLD 1, CLD1, CLD1, CLDN 1, Cldn1, ILVASC, SEMP 1, SEMP1, Senescence associated epithelial membrane protein 1, Senescence associated epithelial membrane protein, Senescence-associated epithelial membrane protein

Immunogen: Synthetic peptide of human CLDN1

Swissprot: O95832
Gene Accession: NP_066924

Calculated MW: 23 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1 mg/mL
Dilution: WB 1:2000-1:5000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-17658/sc-22932/sc-28668

Citation(s):
http://journals.sagepub.com/doi/abs/10.1177/1179550618792254