Claudin 6 polyclonal, anti-human

Quantity: 100 µg

Background:
Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Description:
Rabbit IgG polyclonal antibody for Claudin-6 (CLDN6) detection. Tested with WB in Human.

Synonyms:
Claudin-6 antibody, Claudin6 antibody, CLD6_HUMAN antibody, CLDN 6 antibody, CLDN6 antibody, OTTHUMP00000159248 antibody, Skullin 2 antibody, Skullin antibody, UNQ757/PRO1488 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Claudin 6(204-220aa APAISRGPSEYPTKNYV).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.