Cleaved-Aggrecan (D369) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS7001
Background:
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
Alternative Name:
Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Aggrecan core protein 2, ACAN, AGC1, CSPG1, MSK16
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Cleaved-Aggrecan (D369) polyclonal antibody detects endogenous levels of fragment of activated Aggrecan resulting from cleavage adjacent to Asp369.
Immunogen:
Synthetic peptide, corresponding to amino acids 330-380 of Human Aggrecan.
MW: ~ 97, 250 kDa
Swis Prot.: P16112
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
Alternative Name:
Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Aggrecan core protein 2, ACAN, AGC1, CSPG1, MSK16
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Cleaved-Aggrecan (D369) polyclonal antibody detects endogenous levels of fragment of activated Aggrecan resulting from cleavage adjacent to Asp369.
Immunogen:
Synthetic peptide, corresponding to amino acids 330-380 of Human Aggrecan.
MW: ~ 97, 250 kDa
Swis Prot.: P16112
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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