Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody

Background:
CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

Alternative Names:
CASP6, MCH2, Caspase-6, CASP-6, Apoptotic protease Mch-2

Immunogen: The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 28+35

GeneID: CASP6

Storage: -20°C/1 year

NOTE: For Research Use Only