Cleaved-Integrin α6 LC (E942) Polyclonal Antibody

Background:
integrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Alternative Names:
ITGA6, Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD antigen CD49f

Immunogen: The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 28

GeneID: ITGA6

Storage: -20°C/1 year

NOTE: For Research Use Only