Cleaved-Lamin A (D230-) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS7013
Background:
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.
Alternative Name:
Prelamin-A/C, Lamin-A/C, Lamin A/C, LaminA/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1, Lamin A, LaminA, Lamin-A, Lamin C, LaminC, Lamin-C
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Cleaved-Lamin A (D230-) polyclonal antibody detects the small fragment (28 kDa) of lamin A and lamin C resulting from cleavage at Asp230. The antibody does not cross-react with full length lamin A or lamin C.
Immunogen:
Synthetic peptide, corresponding to amino acids 180-230 of Human Lamin A.
MW: ~ 28 kDa
Swis Prot.: P02545
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.
Alternative Name:
Prelamin-A/C, Lamin-A/C, Lamin A/C, LaminA/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1, Lamin A, LaminA, Lamin-A, Lamin C, LaminC, Lamin-C
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Cleaved-Lamin A (D230-) polyclonal antibody detects the small fragment (28 kDa) of lamin A and lamin C resulting from cleavage at Asp230. The antibody does not cross-react with full length lamin A or lamin C.
Immunogen:
Synthetic peptide, corresponding to amino acids 180-230 of Human Lamin A.
MW: ~ 28 kDa
Swis Prot.: P02545
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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