Cleaved-Spectrin α II (D1185) Polyclonal Antibody

Background:
spectrin alpha, non-erythrocytic 1(SPTAN1) Homo sapiens Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

Alternative Names:
SPTAN1, NEAS, SPTA2, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit

Immunogen: The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 137

GeneID: SPTAN1

Storage: -20°C/1 year

NOTE: For Research Use Only