CLEC3B polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8202
Background:
Tetranectin is a homotrimeric glycoprotein present in plasma and various tissue locations that binds to calcium, heparin, and plasminogen kringle 4. Tetranectin may play a prominent role in tissue remodeling as well as in the regulation of proteolytic processes via its binding and indirect activation of plasminogen. Tetranectin is found in the extracellular matrix (ECM) of certain carcinomas, but is not present in the ECM of normal tissues. Extracellular proteolysis is an important factor in the ability of malignant cells to penetrate normal tissues and metastasize. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and a grim prognosis. Tetranectin may also influence cancer growth by altering activities of plasminogen or the plasminogen fragment, angiostatin which inhibits tumor cell proliferation.
Alternative Name:
Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein, CLEC3B, TNA
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: CLEC3B polyclonal antibody detects endogenous levels of CLEC3B protein.
Immunogen:
Recombinant full length Human CLEC3B.
MW: ~ 23 kDa
Swis Prot.: P05452
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tetranectin is a homotrimeric glycoprotein present in plasma and various tissue locations that binds to calcium, heparin, and plasminogen kringle 4. Tetranectin may play a prominent role in tissue remodeling as well as in the regulation of proteolytic processes via its binding and indirect activation of plasminogen. Tetranectin is found in the extracellular matrix (ECM) of certain carcinomas, but is not present in the ECM of normal tissues. Extracellular proteolysis is an important factor in the ability of malignant cells to penetrate normal tissues and metastasize. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and a grim prognosis. Tetranectin may also influence cancer growth by altering activities of plasminogen or the plasminogen fragment, angiostatin which inhibits tumor cell proliferation.
Alternative Name:
Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein, CLEC3B, TNA
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100
Specificity: CLEC3B polyclonal antibody detects endogenous levels of CLEC3B protein.
Immunogen:
Recombinant full length Human CLEC3B.
MW: ~ 23 kDa
Swis Prot.: P05452
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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