CLIP-170 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71882
Background:
Cytoplasmic linker protein of 170 kDa (CLIP-170) is the original member of a group of microtuble binding proteins designated as plus-end-binding proteins(+TIPs). CLIP-170 binds to the growing plus ends of microtubules and acts as a linker between the dynamic microtubule ends and organelle membranes. The protein acts as an anticatastrophic factor, promoting microtubule rescue near the cell periphery. Fluorescently labeled CLIP-170 can be visualized as a comet like streak around the growing ends of microtubules. CLIP-170 colocalizes with dynactin and dynein at microtubule ends and also at the kinetochore. Restin, first identified as a marker for Hodgkin and Reed-Sternberg (HRS) cells, is a 160 kDa splice variant of the gene that includes a 35 amino acid stretch not present in CLIP-170.
Alternative Name:
CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, CLIP170, Reed-Sternberg intermediate filament-associated protein, Restin, CLIP1, CYLN1, RSN
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: CLIP-170 polyclonal antibody detects endogenous levels of CLIP-170 protein.
Immunogen:
Recombinant protein of human CLIP1
MW: 162kDa
Swis Prot.: P30622
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cytoplasmic linker protein of 170 kDa (CLIP-170) is the original member of a group of microtuble binding proteins designated as plus-end-binding proteins(+TIPs). CLIP-170 binds to the growing plus ends of microtubules and acts as a linker between the dynamic microtubule ends and organelle membranes. The protein acts as an anticatastrophic factor, promoting microtubule rescue near the cell periphery. Fluorescently labeled CLIP-170 can be visualized as a comet like streak around the growing ends of microtubules. CLIP-170 colocalizes with dynactin and dynein at microtubule ends and also at the kinetochore. Restin, first identified as a marker for Hodgkin and Reed-Sternberg (HRS) cells, is a 160 kDa splice variant of the gene that includes a 35 amino acid stretch not present in CLIP-170.
Alternative Name:
CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, CLIP170, Reed-Sternberg intermediate filament-associated protein, Restin, CLIP1, CYLN1, RSN
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: CLIP-170 polyclonal antibody detects endogenous levels of CLIP-170 protein.
Immunogen:
Recombinant protein of human CLIP1
MW: 162kDa
Swis Prot.: P30622
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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