CLK2 Polyclonal Antibody

Background:
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
CDC like kinase 2, CDC-like kinase 2, CLK 2, CLK kinase, CLK2, Clk2 Scamp3, CLK2, Dual specificity protein kinase CLK2, hCLK 2, hCLK2, Tu52

Immunogen: Synthetic peptide of human CLK2

Swissprot: P49760
Gene Accession: NP003984

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.