CNOT2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: CCR4-NOT transcription complex subunit 2(CNOT2) Homo sapiens This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],function:The CCR4-NOT complex functions as general transcription regulation complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CNOT2/3/5 family.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8.,tissue specificity:Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.,

Synonyms: CNOT2, CDC36, NOT2, HSPC131, MSTP046, CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2

Gene Name: CNOT2

Gene ID: 4848

SwissProt ID: Q9NZN8

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.