CNTN1 polyclonal, anti-human, mouse, rat

Background:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.

Synonyms: Contactin-1,Glycoprotein gp135

Cellular Location: Cell membrane Extracellular matrix Cytoplasm

Immunogen:
A synthetic peptide of human CNTN1

Gene Symbol: CNTN1

Gene ID: 1272

Swiss prot: Q12860

Calculated MW: 113/71kDa

Recommended dilution:
IHC 1:100-300

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.