COIL polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8209
Background:
Coilin is the primary protein of nuclear coiled (Cajal) bodies. Cajal bodies are small nuclear organelles and contain many proteins involved in RNA transcription and processing. Coilin is a self-associating protein with a nucleolar localization signal. It is essential for the proper formation of Cajal bodies and for the recruitment of snRNP and survival motor neuron (SMN) complex proteins to Cajal bodies. Coilin directly binds SMN proteins in the recruitment process and competes with SmB’ for SMN interactions. In the developing organism, Cajal bodies play a role in the assembly of the nucleolus. While the N-terminus of coilin contains the self-associating domain, the C-terminus of coilin regulates the number of Cajal bodies present in the cell.
Alternative Name:
Coilin, p80-coilin, COIL, CLN80
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: COIL polyclonal antibody detects endogenous levels of COIL protein.
Immunogen:
Recombinant full length Human COIL.
MW: ~ 63 kDa
Swis Prot.: P38432
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Coilin is the primary protein of nuclear coiled (Cajal) bodies. Cajal bodies are small nuclear organelles and contain many proteins involved in RNA transcription and processing. Coilin is a self-associating protein with a nucleolar localization signal. It is essential for the proper formation of Cajal bodies and for the recruitment of snRNP and survival motor neuron (SMN) complex proteins to Cajal bodies. Coilin directly binds SMN proteins in the recruitment process and competes with SmB’ for SMN interactions. In the developing organism, Cajal bodies play a role in the assembly of the nucleolus. While the N-terminus of coilin contains the self-associating domain, the C-terminus of coilin regulates the number of Cajal bodies present in the cell.
Alternative Name:
Coilin, p80-coilin, COIL, CLN80
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: COIL polyclonal antibody detects endogenous levels of COIL protein.
Immunogen:
Recombinant full length Human COIL.
MW: ~ 63 kDa
Swis Prot.: P38432
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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