COL1A1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70155
Background:
COL1A1 comprises the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Mutations in this protein are also associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor (1).
Alternative Name:
Collagen alpha-1(I) chain, Alpha-1 type I collagen
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: COL1A1 polyclonal antibody detects endogenous levels of COL1A1 protein.
Immunogen:
A synthetic peptide of human COL1A1.
MW: ~ 140 kDa
Swis Prot.: P02452
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
COL1A1 comprises the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Mutations in this protein are also associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor (1).
Alternative Name:
Collagen alpha-1(I) chain, Alpha-1 type I collagen
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: COL1A1 polyclonal antibody detects endogenous levels of COL1A1 protein.
Immunogen:
A synthetic peptide of human COL1A1.
MW: ~ 140 kDa
Swis Prot.: P02452
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review