COL1A1 polyclonal (C-term), anti-human, mouse
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In stock
SKU
AC-AP14490b
Catalog Number: AC-AP14490b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33615
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33615
Applications: WB, IHC-P
Datasheet
Request Information
Background:
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].
Other Names:
Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1
Target/Specificity:
This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.
Antigen Region:
1077-1106
Antigen Type: Synthetic Peptide
Gene Name: COL1A1
Gene ID: 1277
Primary Accession: P02452
NCBI Accession: NP_000079.2
Other Accession: P02454; P11087; P02457; P02453; NP_000079.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].
Other Names:
Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1
Target/Specificity:
This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.
Antigen Region:
1077-1106
Antigen Type: Synthetic Peptide
Gene Name: COL1A1
Gene ID: 1277
Primary Accession: P02452
NCBI Accession: NP_000079.2
Other Accession: P02454; P11087; P02457; P02453; NP_000079.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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