COL25A1 Polyclonal Antibody
€0.00
In stock
SKU
ELK-ES7762
Catalog Number: ELK-ES7762
Reactivity: Human, Mouse
Applications: WB, IHC-p, IF, ELISA
Information
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Questions? Contact us!
Reactivity: Human, Mouse
Applications: WB, IHC-p, IF, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Background:
collagen type XXV alpha 1 chain(COL25A1) Homo sapiens This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Alternative Names:
COL25A1, Collagen alpha-1(XXV) chain, Alzheimer disease amyloid-associated protein, AMY, CLAC-P
Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 64
GeneID: COL25A1
Storage: -20°C/1 year
NOTE: For Research Use Only
collagen type XXV alpha 1 chain(COL25A1) Homo sapiens This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Alternative Names:
COL25A1, Collagen alpha-1(XXV) chain, Alzheimer disease amyloid-associated protein, AMY, CLAC-P
Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 64
GeneID: COL25A1
Storage: -20°C/1 year
NOTE: For Research Use Only
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