Collagen I alpha 1 (Cleaved-Ala1218) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone| cornea| dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV| Ehlers-Danlos syndrome type VIIA| Ehlers-Danlos syndrome Classical type| Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor. Two transcripts| resulting from the use of alternate polyadenylation signals| have been identified for this gene.

Research Area: Signal transduction, Stem cells

Synonyms: Collagen I α1 , Cleaved-Ala1218, Collagen alpha-1, I chain, Alpha-1 type I collagen

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year