Collagen I polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands; Cellular antigens; Receptors and Channels; Cell Adhesion Molecules

Pathway and Disease: Cancers, Signaling Molecules and Interaction, Cell Communication

Description:
Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Defects in one or both alleles of the type I collagen gene causes "brittle bone disease" (osteogenesis imperfecta). Patients suffering from such defects have low levels of fully functional type I collagen resulting in fragile bones.

Alternate Names: Collagen I, Collagen Type I, Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P02452

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal propeptide region of human collagen I.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] KC Yang et al. 2015. School of Dental Technology, College of Oral Medicine, Taipei Medical University. Apr
40(4):E39-50. PMID: 26582651.
[2] Lee S et al. 2015. Laryngoscope. 125(8): 1900-7. PMID 25891493.
[3] Kim H et al. 2012. Chemistry and Material Science. Biotechnology and Bioprocess Engineering. 17(3):465-474. PMID# 21142100.
[4] Wu C et al. 2012. Elsevier. Process Biochemistry. 47(6):922-928.