Collagen IV polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Description:
Rabbit IgG polyclonal antibody for Collagen alpha-2 (IV) chain (COL4A2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.

Synonyms:
Arresten antibody, Canstatin antibody, CO4A1_HUMAN antibody, COL4A1 antibody, COL4A1 NC1 domain antibody, COL4A2 antibody, COL4A3 antibody, COL4A4 antibody, COL4A5 antibody, Collagen Alpha 1(IV) Chain antibody, Collagen Alpha 2(IV) Chain antibody, collagen alpha-1(IV) chain antibody, Collagen IV Alpha 1 Polypeptide antibody, Collagen IV Alpha 2 Polypeptide antibody, Collagen Of Basement Membrane Alpha 1 Chain antibody, Collagen Of Basement Membrane Alpha 2 Chain antibody, Collagen Type IV Alpha 1 antibody, Collagen Type IV Alpha 2 antibody, Collagen Type IV Alpha 3 antibody, Collagen Type IV Alpha 4 antibody, Collagen Type IV Alpha 5 antibody, DKFZp686I14213 antibody, FLJ22259 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen IV(1697-1712aa LIRTHISRCQVCMKNL), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.