Collagen VI polyclonal, anti-human, mouse, rat

Background:
This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Alternative Name:
COL6A1, COL6A2, COL6A3, Alpha 1 (VI) chain (61 AA), CO6A1, COL6A1, COL6A2, COL6A3, Collagen alpha 2(VI) chain, Collagen alpha 3(VI) chain, Collagen alpha-1(VI) chain, Collagen type VI alpha 1, Collagen type VI alpha 2, Collagen type VI alpha 3, Collagen VI alpha 1 polypeptide, Collagen VI alpha 2 polypeptide, Collagen VI alpha 3 polypeptide, CollagenVI, Human mRNA for collagen VI alpha 2 C terminal globular domain, OPLL, PP3610,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:50-1:200

Specificity: Collagen VI polyclonal antibody detects endogenous levels of Collagen VI protein.

Immunogen:
recombinant protein

MW: 134/109 kDa

Swiss-Prot: P12109(Human) P12110(Human) P12111(Human) Q02788(Mouse) Q04857(Mouse) Unigene:232118(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.