COMP Polyclonal Antibody

Background:
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Research Area: Cancer, Cell Biology, Signal Transduction, Stem Cells

Synonyms:
COMP, EDM1, EPD1, MED, PSACH, THBS5, TSP5

Immunogen: Recombinant fusion protein of human COMP (NP_000086.2).

Swissprot: P49747
Gene ID: 1311

Calculated MW: 77 kDa/82 kDa
Observed MW: 110 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:10-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.