Complement Component 4 polyclonal, anti-human

Quantity: 100 µl

Background:
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description:
Chicken polyclonal to human Complement Component C4

Synonyms:
C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2

Isotype: Chicken Polyclonal

Immunogen:
Human Complement Component C4

Form: Chicken IgY Affinity Purified, in PBS containing 0.1% sodium azide

Specificity:
Human Complement Component C4

Reactivity: human

Applications: ELISA, Electroblotting

Working DIlution: ELISA, min. 1:1,000; Electroblotting, 1:1,000. Optimal dilution should be determined by user

Storage: 2-8C, Avoid freezing temperature