COMT antibody (clone 1G4-1A1), anti-human
€435.00
In stock
SKU
AC-AT1588a
Catalog Number: AC-AT1588a
Size: 100 µg
Isotype: mouse IgG2b kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2b kappa
Applications: WB, E
Request Information AC-AT1588a">Request Information
Background:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Antigen Type:
Recombinant Protein
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
NCBI Accession: NP_000745.1;NP_001128633.1;NP_001128634.1;NP_009294.1
Primary Accession: P21964
Other Accession: BC000419
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Antigen Type:
Recombinant Protein
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
NCBI Accession: NP_000745.1;NP_001128633.1;NP_001128634.1;NP_009294.1
Primary Accession: P21964
Other Accession: BC000419
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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