COMT Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP10956a
Background:
Catechol-O-methyltransferase catalyzes the transfer of amethyl group from S-adenosylmethionine to catecholamines, includingthe neurotransmitters dopamine, epinephrine, and norepinephrine.This O-methylation results in one of the major degradative pathwaysof the catecholamine transmitters. In addition to its role in themetabolism of endogenous substances, COMT is important in themetabolism of catechol drugs used in the treatment of hypertension,asthma, and Parkinson disease. COMT is found in two forms intissues, a soluble form (S-COMT) and a membrane-bound form(MB-COMT). The differences between S-COMT and MB-COMT reside withinthe N-termini. Several transcript variants are formed through theuse of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
Primary Accession: P21964
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Catechol-O-methyltransferase catalyzes the transfer of amethyl group from S-adenosylmethionine to catecholamines, includingthe neurotransmitters dopamine, epinephrine, and norepinephrine.This O-methylation results in one of the major degradative pathwaysof the catecholamine transmitters. In addition to its role in themetabolism of endogenous substances, COMT is important in themetabolism of catechol drugs used in the treatment of hypertension,asthma, and Parkinson disease. COMT is found in two forms intissues, a soluble form (S-COMT) and a membrane-bound form(MB-COMT). The differences between S-COMT and MB-COMT reside withinthe N-termini. Several transcript variants are formed through theuse of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
Primary Accession: P21964
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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