COMT monoclonal (N-term) (Ascites), anti-human
€470.00
In stock
SKU
AC-AM2164a
Catalog Number: AC-AM2164a
Size: 100 µl
Isotype: mouse IgG1
Clone Name: 630CT1.7.1
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgG1
Clone Name: 630CT1.7.1
Applications: WB
Datasheet
Request Information
Background:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Target/Specificity:
This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.
Antigen Region:
37-65
Antigen Type: Synthetic Peptide
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
Primary Accession: P21964
NCBI Accession: NP_000745.1;NP_001128633.1;NP_001128634.1;NP_009294.1
Other Accession: NP_000745.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Other Names:
Catechol O-methyltransferase, COMT
Target/Specificity:
This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.
Antigen Region:
37-65
Antigen Type: Synthetic Peptide
Gene Name: COMT (HGNC:2228)
Gene ID: 1312
Primary Accession: P21964
NCBI Accession: NP_000745.1;NP_001128633.1;NP_001128634.1;NP_009294.1
Other Accession: NP_000745.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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