Connexin 31 polyclonal (C-term), anti-human
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In stock
SKU
AC-AP1543b
Catalog Number: AC-AP1543b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0445
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0445
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Other Names:
Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31
Target/Specificity:
This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.
Antigen Region:
227-257
Antigen Type: Synthetic Peptide
Gene Name: GJB3
Gene ID: 2707
Primary Accession: O75712
NCBI Accession: NP_001005752.1;NP_076872.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Other Names:
Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31
Target/Specificity:
This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.
Antigen Region:
227-257
Antigen Type: Synthetic Peptide
Gene Name: GJB3
Gene ID: 2707
Primary Accession: O75712
NCBI Accession: NP_001005752.1;NP_076872.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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